Bioclinic Naturals Opti Ova Female Wellness Kit

Opti Ova is a comprehensive female reproductive support kit that provides an effective combination of key antioxidants, omega-3 fatty acids, vitamins, and minerals proven to improve egg quality and enhance fertility. By optimizing mitochondrial function, reducing oxidative stress, supporting blood flow to the endometrium and its development, and enhancing detoxification pathways, Opti Ova provides a broad base of nutritional support for reproductive health. Mitochondrial activity is a key factor in oocyte function and quality, with mitochondrial dysfunction recognized as a major cause of age-induced decline in oocyte quality. Key nutrients, including PQQ, resveratrol, and CoQ10, have been shown to induce mitochondrial biogenesis, counteract ovarian aging and when combined with standard treatments, CoQ10 supplementation resulted in a more than 6-fold increase in the clinical pregnancy rate than clomiphene alone, in a randomized prospective trial of participants with PCOS.

N-acetylcysteine provides the limiting factor for glutathione production, essential for detoxification of many pollutants which interfere with reproductive function; it has also been shown to improve pregnancy rates and endometrial thickness when compared to standard treatments for PCOS, such as clomiphene and metformin.¹⁰

Opti Ova includes vitamins D and E, omega-3 fatty acids, lipoic acid, and bioavailable B vitamins which act as potent antioxidants and support optimal endometrial health and implantation. Vitamin E supplementation alone has been shown to shorten the time to pregnancy among women older than 35 seeking treatment for unexplained infertility, while vitamin D has been linked to implantation rates and IVF outcomes, with the highest levels linked to the highest pregnancy rates.

Benefits of Opti Ova: Provides comprehensive nutritional support, with therapeutic dosages, for diverse factors affecting reproductive health; Broad spectrum antioxidants reduce oxidative stress and damage and enhance mitochondrial function, key determinants of oocyte function and quality; Provides the most bioavailable forms of nutrients, including pyridoxal 5-phosphate, mixed tocopherols, vitamin D3, methylcobalamin and L-5-methyltetrahydrofolate; Supports proper endometrial blood flow, supplying nutrients, removing toxins and reactive oxygen species (ROS) from the endometrium, encouraging proper implantation.

Ingredients:

Recommended Adult Dose: 1 packet per day or as directed by a health care practitioner. Consult a health care practitioner for use beyond 3 months.

Cautions:

Vitamin E: Consult a health care practitioner prior to use if you have cancer, cardiovascular disease, diabetes, or are taking blood thinners.

CerebroVital PQQ-10: Consult a health care practitioner prior to use if you are pregnant or breastfeeding, or are taking blood pressure medication or blood thinners.  

NAC & ALA: Consult a health care practitioner prior to use if you are pregnant or breastfeeding, or if you have diabetes or kidney stones. Do not use this product if you are taking antibiotics or vasodilators (dilate the vascular system to treat heart conditions).

B Complex-Pro: People sensitive to nicotinic acid may experience flushing of the skin that is generally mild and transient.

Keep out of reach of children.

References:

1. Schatten H, Sun QY, Prather R. The impact of mitochondrial function/dysfunction on IVF and new treatment possibilities for infertility. Reprod Biol Endocrinol. 2014 Nov 24;12:111. doi: 10.1186/1477-7827-12-111.
2. Oktay K, Baltaci V, Sonmezer M, et al. Oogonial Precursor Cell-Derived Autologous Mitochondria Injection to Improve Outcomes in Women With Multiple IVF Failures Due to Low Oocyte Quality: A Clinical Translation. Reprod Sci. 2015 Dec;22(12):1612-7. doi: 10.1177/1933719115612137.
3. Chowanadisai W, Bauerly KA, Tchaparian E, et al. Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression. J Biol Chem. 2010 Jan 1;285(1):142-52.
4. Ben-Meir A, Burstein E, Borrego-Alvarez A., et al. Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging. Aging Cell. 2015 Oct;14(5):887-95.
5. Özcan P, Fiçicioglu C, Kizilkale O, et al. Can Coenzyme Q10 supplementation protect the ovarian reserve against oxidative damage? J Assist Reprod Genet. 2016 Jun 3. [Epub ahead of print]
6. Özcan P, Fiçicioglu C, Yildirim ÖK, et al. Protective effect of resveratrol against oxidative damage to ovarian reserve in female Sprague-Dawley rats. Reprod Biomed Online. 2015 Sep;31(3):404-10.
7. El Refaeey A, Selem A, Badawy A. Combined coenzyme Q10 and clomiphene citrate for ovulation induction in clomiphene-citrate-resistant polycystic ovary syndrome. Reprod Biomed Online. 2014 Jul;29(1):119-24.
8. Ziv-Gal A, Flaws JA. Evidence for bisphenol A-induced female infertility: review (2007-2016). Fertil Steril. 2016 Jul 11. pii: S0015-0282(16)61382-1.
9. Jain S, Kumar CH, Suranagi UD, et al. Protective effect of N-acetylcysteine on bisphenol A-induced cognitive dysfunction and oxidative stress in rats. Food Chem Toxicol. 2011 Jun;49(6):1404-9.
10. Maged AM, Elsawah H, Abdelhafez A, et al. The adjuvant effect of metformin and N-acetylcysteine to clomiphene citrate in induction of ovulation in patients with Polycystic Ovary Syndrome. Gynecol Endocrinol. 2015;31(8):635-8.
11. Visioli F, Hagen TM. Antioxidants to enhance fertility: role of eNOS and potential benefits. Pharmacol Res. 2011 Nov;64(5):431-7.
12. Ruder EH, Hartman TJ, Reindollar RH, et al. Female dietary antioxidant intake and time to pregnancy among couples treated for unexplained infertility. Fertil Steril. 2014 Mar;101(3):759-66.
13. Farzadi L, Khayatzadeh Bidgoli H, Ghojazadeh M. et al. Correlation between follicular fluid 25-OH vitamin D and assisted reproductive outcomes. Iran J Reprod Med. 2015 Jun;13(6):361-6.
14. Ozkan S, Jindal S, Greenseid K, et al. Replete vitamin D stores predict reproductive success following in vitro fertilization. Fertil Steril. 2010 Sep;94(4):1314-9.
15. Paffoni A, Ferrari S, Viganò P, et al. Vitamin D deficiency and infertility: insights from in vitro fertilization cycles. J Clin Endocrinol Metab. 2014 Nov;99(11):E2372-6.
16. Kellermann AJ, Kloft C. Is there a risk of bleeding associated with standardized Ginkgo biloba extract therapy? A systematic review and meta-analysis. Pharmacotherapy. 2011 May;31(5):490-502. doi: 10.1592/phco.31.5.490.
17. Kromhout D, de Goede J. Update on cardiometabolic health effects of ω-3 fatty acids. Curr Opin Lipidol. 2014 Feb;25(1):85-90.
18. Diamond BJ, Bailey MR. Ginkgo biloba: indications, mechanisms, and safety. Psychiatr Clin North Am. 2013 Mar;36(1):73-83.
19. Harris WS. Expert opinion: omega-3 fatty acids and bleeding-cause for concern? Am J Cardiol. 2007 Mar 19;99(6A):44C-46C.
20. Toyama K, Nishioka T, Isshiki A, et al. Eicosapentaenoic Acid combined with optimal statin therapy improves endothelial dysfunction in patients with coronary artery disease. Cardiovasc Drugs Ther. 2014 Feb;28(1):53-9.
21. Mischoulon D, Freeman MP. Omega-3 fatty acids in psychiatry. Psychiatr Clin North Am. 2013 Mar;36(1):15-23.