Men's Health Supplements for Weight Loss | 10 Best Supplements for Weight Loss for Men

Obesity is common worldwide and it has doubled during the past two decades among men. Obesity is associated with different health problems which altogether referred to as metabolic syndrome. Insulin resistance is a key element to metabolic syndrome. Insulin resistance is related to many factors such as lifestyle, aging, eating habits, poor digestion, and hormones. Increasing concerns in this area of health has initiated many scientific research to explore the causes of the obesity and its relation to other major health problems. Researcher have been looking at wide range of aspects that could influence weight gain from genetic to mood, and sedentary lifestyle.

Men mainly gather weight around the waist, where it circulates through the liver impacting metabolism of nutrients which commonly demonstrate itself through fatty liver, diabetes, and disturbance in hormone production.

What are the main causes of weight gain in men?

Often weight gain is justified through reasons such as it runs in my family or we have poor metabolism. While genetic conditions may play a role in developing obesity in a small percentage of the population, it clearly can't be the main cause of recent significant increase in obesity, due to the fact that the human genomic evolution does not take place within short period of two decades. Data from many research suggest that some people are more predisposed to gain more weight than others, while there is no genetic factor in play. In fact, research associates the rapid weight gain in infancy with a higher risk of adult obesity due to the development of metabolic patterns in infancy and childhood that continue to influence the eating habits and metabolism throughout the life.

Statistical studies suggest that commonly men tend to eat much more calorie dense and bigger meal portions in one 

sitting. Based on the information from research those participants whom fed bigger meal portions accumulated 5000 more calories than the control group only within 11 days. Although it may be difficult to convince people to eat smaller portions, eating less energy dense meals has shown to make a remarkable difference.

In another study a group of six healthy men who were subjected to eat ~6000 kcal/day of the common U.S. diet [~50% carbohydrate, ~ 35% fat, and ~15% protein] for 1 week while performing no physical activity, rapidly gained 3.5 kg, and within 2-3 days demonstrated the onset of the Insulin resistance due to increased oxidative stress which causes higher oxidation of Glucose Transport Protein ( GLUT4) and therefore loss of its function. This study concluded that excessive caloric intake acutely causes oxidative stress, GLUT4 dysfunction, and insulin resistance in healthy men.

Hormones are also play a role in weight gain. Although low level testosterone can contribute to weight gain, it is important to be aware of misinterpretation that it has caused amongst practitioners and patients. It is essential to separate the low testosterone level due to a disease or condition impacting HPTaxis function (hypothalamic–pituitary–testicular function) from testosterone decline due metabolic factors and aging. It is known that low testosterone level and obesity are linked however in reality which is cause and which is effect?

Insufficient testosterone production due to interruption in the HPTaxis function even in a smaller scale, causes metabolic disease, high fat accumulation, high cholesterol, heart disease, insulin resistance, high blood sugar, diabetes, and obesity. This association of low testosterone with metabolic syndrome is age independent and it might be subtle and gradual with delayed side effects or it could be sudden with immediate manifestation such as changing in mood, and rapid weight gain.

Studies of men undergoing testosterone-lowering androgen deprivation therapies for prostate cancer showed decreased insulin sensitivity and increased body fat mass.  In one study, more than 50% of men undergoing long-term androgen deprivation therapy developed the metabolic syndrome, manifested in particular by increased abdominal obesity and elevated blood sugar.

Other point of view suggests that obesity comes first, and low testosterone is simply the result. That is true, because fat tissue is an extremely active hormonal modulator, particularly for testosterone and estrogen. Fatty tissue increases aromatase enzyme activity which converts the testosterone into estradiol resulting in lower levels of testosterone.

Aromatase, also called estrogen synthetase, and it is a key enzyme is biosynthesis of estrogen. Particularly aromatase is responsible for converting androgen into estrogen. The aromatase can be found in various tissues including gonads, brain, fat tissue, blood vessels, skin, and bone. Certain factors are known to increase aromatase activity such as aging, obesity, and alcohol.

Aging makes it more difficult to lose weight. Because naturally the testosterone production is decreased, while the aromatase activity has increased contributing to more reduction in testosterone. As a result, during andropause body accumulates more of deep abdominal fat tissue, and gradually inflammatory markers increase initiating metabolic disease.

Testosterone replacement has increasingly being offered to older men with age-related decline in testosterone levels. Studies have examined the effects of long-term testosterone replacement and aromatase inhibition (AI) on glucose metabolism and other cardiovascular markers.

In a randomized double blind pelacebo-controlled trial, older non-diabetic men (age 65-73) with low testosterone levels were treated either with Trans-dermal Testosterone or Aromatase Inhibitor for the period of 12 months. Results showed the abdominal subcutaneous fat and Leptin level were significantly lower in aromatase inhibitor group, while the fasting lipids and inflammatory marker C-reactive protein (CRP) remained similar to the control group for both treatments.

Other studies have assessed the compared the effects of short-term aromatase inhibition on glucose metabolism, lipid profile, and adipo-cytokine levels (inflammatory markers) in young and elderly men. Short-term aromatase inhibition appears to affect glucose metabolism in young men, and lipid metabolism, including leptin secretion, in both young and elderly men. 

How to improve and maintain healthy weight in men?

Repeated overeating can be a major source of excess calories that may lead to weight gain. Also, Studies are shown that even short term overeating impairs the insulin effect. Over eating causes the brain not to respond to normal amounts insulin which is known as insulin resistance condition. This initiates the path to diabetes, metabolic syndrome and obesity. Implementing low calorie dense foods, higher intake of fibre and lean protein are proven steps to stabilize the insulin level and prevent he insulin resistance condition.

Compelling amount of data suggest that there is link between stress and over eating. The stress exposure lead to a stronger drive to eat and may be one factor promoting excessive weight gain. In humans, exposure to stressors and self-reported stress are associated with greater food intake. Higher levels of stress, both exposure and perception, was associated with greater desire to eat-including feelings of dis-inhibited eating, binge eating, hunger, and more ineffective attempts to control eating.

L teanine is an amino acid derived from green tea. L-theanine is shown various benefits for human health. Based on many human studies L-theanine can be used to treat nutritional and metabolic diseases by providing antiobesity effects, suppressing the body weight increases and fat accumulation and exerting antidiabetic effects. L Theanine is able to cross the blood–brain barrier and reduces mental and physical stress.

Declining testosterone levels are linked to a steady rise in inflammatory markers such as C-reactive protein (CRP). Inflammation plays a critical role in development of obesity. Inflammation is also involved in insulin resistance and type 2 diabetes. Simultaneously, higher fat tissue formation due to the testosterone deficiency creates more of the inflammatory cytokine which further enhaces the cycle of inflammation, insulin resistance, and cardiovascular disease that constitutes the metabolic syndrome.

Reduced testosterone levels due to its lower production and an increase in its conversion to unwanted estrogen with age may be one of the reasons to promote weight gain in men at or beyond middle age. Therefore avoiding estrogenic factors such as soy milk and estrogenic toxins, and eliminating the aromatase activating factors such as alcohol and inflammation, and boosting the aromatase inhibition is found to be effective.

To date a large number of natural product metabolites, of various compound classes, have been evaluated for their ability to inhibit the aromatase enzyme. Cellular and in vivo aromatase inhibition methods are commonly used to biologically evaluate some of these natural product.  Natural aromatase inhibitors have been the object of growing attention in recent years because of their potential to inhibit aromatase with fewer side effects.

Resveretrol rich foods and supplements are found to effectively reduce the activity of the aromatase enzyme. Cell studies have shown that resveratrol can inhibit the production of gene-toxic estradiol and and prevents damage to genetic material. Trans-Resveratrol is reportedly has shown many health benefits including anticarcinogenic effects and protection against cardiovascular disease.

One of the mechanisms by which resveratrol works is via modulating the estrogen response systems. Resveratrol is studied for its beneficial effects on the men's health, because estrogen is involved in male reproductive biology. Animal studies were indicative of significantly higher serum concentrations of gonadotrophins and testosterone in the resveratrol-treated group.

Dietary flavonoids such as flavones and flavonones are shown to provide high aromatase-inhibitory function. One of the most powerful flavones include chrysin which is found in passionflower and apignine which is found in chamomile. 

Flavonones are found in citrus fruits and specially in lemons and limes. They are classically known as citrus bioflavonoids including diosmin, hesperidin, rutin, naringin, tangeretin, diosmetin, narirutin, neohesperidin, nobiletin and quercetin.

Cruciferous vegetables such as broccoli, cauliflower, kale, brussel sprouts, are all natural aromatase inhibitors. Cruciferous veggies are rich in a compound called 3,3′-Diindolylmethane (DIM) and Indole-3 Carbonyl (I3C) . DIM is a metabolite of I3C. DIM is not only a powerful aromatase inhibitor, but also effectively metabolizes estrogen molecules and helps the liver to remove them.

Zinc is one of the powerful aromatase inhibitors. Studies have found those with Zinc deficiency have more estrogen receptor sites.These findings are indicative of that the zinc deficiency causes lower levels of circulating luteinizing hormone and testosterone concentrations, alters hepatic steroid metabolism, and modifies the estrogen and testosterone hormone receptor levels.

Healthy fats including Omega 3s, olive oil, and raw nuts are protecting against estrogens. Raw nuts and Olive oil are rich in plant sterols that support testosterone production in men. Sterols may also protect against prostate enlargement. Omega 3 fatty acids include DHA and EPA which provide anti-inflammatory benefits that can reduce the pro inflammatory affects of estrogen.

Natural compound called honokiol sourced from the bark and leaves of magnolia tree and found to be able to modulate the testosterone level in men. In vitro tests identified this compound as a very effective inhibitor of aromatase. Honokiol is commonly taken orally. There are a number of supplements available containing honokiol known as relora.

Honokiol is able to pass the blood-brain barrier, it is highly bio-available and provides several therapeutic benefits and it is used for a number of conditions related to central nervous system, cardiovascular system, and gastrointestinal system. It has been shown to have anti-tumor, anti-inflammatory, and antioxidant effects as well.

Including foods such as Cruciferous vegetables inculding broccoli, cauliflower, cabbage, brussels sprouts, cauliflower, and kale that inhibit aromatase is one of the best things to maintain healthy testosterone levels.

Complementing the daily routines with aromatase inhibiting supplements will help to increase availability of the natural testosterone that the body produces resulting is more bio-available testosterone in your body, and increased health.

Keeping stress whether its perceptional or due to external factors under control, getting to exercise, reducing the rich high calorie diet, and avoiding estrogenic foods and toxins will maximize the results with added benefits.

Articles and products featured by Health Palace are collected from a variety of sources and are provided as a service by Health Palace. These newsletters, while of potential interest to readers, do not necessarily represent the opinions nor constitute the advice of Health Palace. Presented materials are only for information purposes and do not intent to treat, cure, or prevent any disease.

Related Articles:

• Keep a Healthy Testosterone Level in Adult Men
• How to Maintain and Restore Healthy Blood Lipids Level
• Simple yet Important Nutrients Men Should Include in Their Daily Routine
• How Chronic Stress Affects Men's Health

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