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How Does Dry Skin Affect Your Health Skin in the largest human organ. Skin represents 15 % the body mass with approximately two square meters of surface which is both protective and permeable. Skin is consists of multilayer tissue separating the body from the environment. Skin is responsible for many important functions including: temperature regulation by both providing insulation and via perspiration, water transport, sensations like touch, heath and cold, and protection by providin …